Abstract
Abstract
The anti-inflammatory effects of ethanolic crude extracts of Amaranthus viridis whole plant was investigated in carrageenan induced rat paw oedema. Albino Rats were classified into four groups, each of 5 . Group 1 received (0.1 ml of 1% W/V carrageenan in 0.9 ml normal saline in a dose of 2 ml/kg body weight ) at sub-plantar region and served as negative control , group 2 received indomethacin ( 10 mg/kg bwt ) intraperitoneally and served as standard reference ( positive control ) , group 3 and group 4 received crude ethanolic extract intraperitoneally at 250 mg/kg and 500 mg/kg bwt respectively. The oedema was quantified by measuring the hind paws thickness at 0, 1, 2 and 3 hour after the carrageenan injection. Administration of ethanolic extract (250 mg/kg and 500 mg/kg) significantly reduced the oedema thickness in a time and dose dependent manner. The inhibition percentage of inflammation was 40.30 % and 70.4 % at dose of 250 and 500 mg/kg respectively. The ethanolic extract at dose of 500 mg/kg shows a potent activity at the last hour of following up. The present study concluded that Amaranthus viridis extract displays remarkable anti-inflammatory activity and recommended for the possible use as anti-inflammatory remedy.
Key words: anti-inflammatory, Amaranthus viridis, Albino Rats